Do Price Uncertainties Affect the Use of Policy Flexibilities? The Selection of Sensitive Products in WTO Agricultural Negotiations

In a context in which price uncertainty is likely to increase, expected market trends need to be taken carefully into account while negotiating international trade policy rules. This paper aims at analyzing what is their influence on the use of policy flexibilities in the context of WTO agricultural negotiations. In particular, within the market access pillar, we focus on the selection of sensitive products. Our model, TRIMAG (Tariff Reduction Impact Model for Agriculture), defined at the 8-digit level, optimizes the domestic agricultural value added subject to a maximum number of sensitive tariff lines, accounting for various future international price scenarios. Furthermore, we test the use of alternative options for the implementation of “tariff simplification”. Findings confirm that the future expected development of world and domestic prices plays an important role in the selection of sensitive products, and that tariff simplification doesn’t affect the results, if provisions to ensure the neutrality of the exercise are put in place. Furthermore, TRIMAG can be considered as a tariff aggregation tool that can be linked to agricultural simulation models that operate at a higher level of aggregation.WTO agricultural negotiations, market access, sensitive products, International Relations/Trade, F13, Q17,

Risk Based Maintenance for Swiss Railway Bridges: Concept, Implementation and First Experiences

The Swiss Federal Railway (SBB) has an inventory of approx. 6,000 bridges. So far, condition classes of the individual bridges have been used for maintenance management. To improve the efficiency of the maintenance management, a long-term change from the condition class-based approach to a risk-based approach is considered. Such a risk-based approach was developed and implemented during a two-stage process into software (Excel and Python). The software was also linked to the SBB databases to access the relevant data. The Python software now includes 12 parameters to adapt the initial failure probability to specific bridge conditions and 15 damage parameters. So almost 30 parameters are used to compute the risk for each bridge. The software is also linked to geographical maps to show the location of the bridges. Besides the development of the approach, also the first experience of the application of this methodology will be discussed. For example, the risk-based ranking of the bridges clearly showed that specific bridge types are dominating. Also, some original ideas and concepts were not applicable due to difficulties in providing the required input data. However, currently the risk-based bridge ranking complies well with former investigations carried out by hand

Risk based maintenance for Swiss railway bridges: concept, implementation and first experiences

The Swiss Federal Railway (SBB) has an inventory of approx. 6,000 bridges. So far, condition classes of the individual bridges have been used for maintenance management. To improve the efficiency of the maintenance management, a long-term change from the condition class-based approach to a risk-based approach is considered. Such a risk-based approach was developed and implemented during a two-stage process into software (Excel and Python). The software was also linked to the SBB databases to access the relevant data. The Python software now includes 12 parameters to adapt the initial failure probability to specific bridge conditions and 15 damage parameters. So almost 30 parameters are used to compute the risk for each bridge. The software is also linked to geographical maps to show the location of the bridges. Besides the development of the approach, also the first experience of the application of this methodology will be discussed. For example, the risk-based ranking of the bridges clearly showed that specific bridge types are dominating. Also, some original ideas and concepts were not applicable due to difficulties in providing the required input data. However, currently the risk-based bridge ranking complies well with former investigations carried out by hand

Circadian rhythm dysfunction in glaucoma: A hypothesis

The absence of circadian zeitgebers in the social environment causes circadian misalignment, which is often associated with sleep disturbances. Circadian misalignment, defined as a mismatch between the sleep-wake cycle and the timing of the circadian system, can occur either because of inadequate exposure to the light-dark cycle, the most important synchronizer of the circadian system, or reduction in light transmission resulting from ophthalmic diseases (e.g., senile miosis, cataract, diabetic retinopathy, macular degeneration, retinitis pigmentosa, and glaucoma). We propose that glaucoma may be the primary ocular disease that directly compromises photic input to the circadian time-keeping system because of inherent ganglion cell death. Glaucomatous damage to the ganglion cell layer might be particularly harmful to melanopsin. According to histologic and circadian data, a subset of intrinsically photoresponsive retinal ganglion cells, expressing melanopsin and cryptochromes, entrain the endogenous circadian system via transduction of photic input to the thalamus, projecting either to the suprachiasmatic nucleus or the lateral geniculate nucleus. Glaucoma provides a unique opportunity to explore whether in fact light transmission to the circadian system is compromised as a result of ganglion cell loss

Management of Hypertension among Patients with Coronary Heart Disease

Evidence suggests that coronary heart disease (CHD) is the most common outcome of hypertension. Hypertension accelerates the development of atherosclerosis, and sustained elevation of blood pressure (BP) can destabilize vascular lesions and precipitate acute coronary events. Hypertension can cause myocardial ischemia in the absence of CHD. These cardiovascular risks attributed to hypertension can be reduced by optimal BP control. Although several antihypertensive agents exist, the choice of agent and the appropriate target BP for patients with CHD remain controversial. In this succinct paper, we examine the evidence and the mechanisms for the linkage between hypertension and CHD and we discuss the treatment options and the goals of therapy that are consistent with the report of the seventh Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) and American Heart Association scientific statement. We anticipate changes in the recommendations of the forthcoming JNC 8

Pressure natriuresis in isolated kidneys from hypertension-prone and hypertension-resistant rats (Dahl rats)11Dr. Dahl, with whom we were collaborating, died just as this work was beginning. We wish to dedicate this paper to his memory.

Pressure natriuresis in isolated kidneys from hypertension-prone and hypertension-resistant rats (Dahl rats). Dahl described a strain of rats with genetically controlled propensities for hypertension. Chronic excess salt feeding increased blood pressure in sensitive (S) rats, whereas resistant rats (R) remain normotensive. We tested the pressure natriuretic function (urinary sodium excretion versus perfusion pressure) in isolated kidneys perfused with a cellular medium: in sodium-restricted normotensive sensitive (S0) and resistant (R0) animals; in sensitive rats receiving a high-salt diet for 3 weeks (S3); and in both S and R animals exposed to excess sodium for 7 weeks (R7 and S7). The aim of these studies was to determine if a preset alteration of the pressure natriuretic function might be present in S animals prior to the development of hypertension. Systolic blood pressure in S0, S3, and S7animals were 123 ± 4, 136 ± 2, and 162 ± 4mm Hg, respectively, whereas that of R0 and R7 were 121 ± 5 and 126 ± 5mm Hg. An increase of the perfusion pressure of isolated kidneys from 105 to 185mm Hg in stepwise fashion resulted in a pressure natriuresis whose slope was similar in R0 and S0 animals. Of interest was that the pressure natriuretic function slope of kidneys from R0(low sodium) and R7 (high sodium) rats was as predicted by the Guyton system analysis of normal blood pressure control. Micropuncture of the proximal nephrons demonstrated that the origin of the natriuresis resulted from a site beyond the accessible proximal tubule. Results from S7 kidneys contrasted with all others in that the natriuretic response was depressed (P < 0.01), which resulted from significantly lower filtration rates at higher perfusion pressures. We concluded (1) in normal R rats, the pressure natriuretic function is that predicted by the Guyton hypothesis, (2) Dahl S animals have no preset abnormality of this function until hypertension is present for some time, and (3) a depression of the pressure natriuretic function may aggravate hypertension in S rats once high blood pressure has persisted.Natriurèse de pression dans les reins isolés provenant de rats de Dahl sensibles ou résistants à l'hypertension. Dahl a décrit une souche de rats ayant une propension génétique à l'hypertension. L'administration d'une alimentation riche en sel augmente la pression artérielle chez les rats sensibles (S) alors que les rats résistants (R) restent normotendus. Nous avons étudié la natriurèse de pression (excrétion urinaire de sodium en fonction de la pression de perfusion) dans des reins isolés perfuses avec un milieu cellulaire provenant de rats normotendus S0 et R0 soumis à une restriction de sodium, de rats sensibles ayant reçu une alimentation riche en sel pendant trois semaines (S3) et de rats S et R exposés à un excès de sel pendant 7 semaines (R7 et S7). Le but de ces études est d'établir l'existence éventuelle d'une modification de la relation pression natriurèse avant le développement de l'hypertension. Les pressions systoliques des rats, S0, S3, et S7 étaient de 123 ± 4, 136 ± 2, et 162 ± 4mm Hg, respectivement, alors que celles de R0 et R7 étaient de 121 ± 5 et 126 ± 5mm Hg. Une augmentation de la pression de perfusion de reins isolés de 105 à 185mm Hg, par paliers, a eu pour résultat une natriurèse de pression dont la pente était la même chez R0 et S0. Il est intéressant de remarquer que la pente de cette relation pour les reins R0 (sodium bas) et R7 (sodium élevé) est celle qui est prévue par l'analyse de Guyton du contrôle normal de la pression artérielle. Des microponctions des néphrons proximaux ont montré que l'origine de la natriurèse est en aval du tuble proximal accessible. Les résultats des reins S7 ont été différents de tous les autres en ce sens que la réponse natriurétique a été déprimée (P < 0,001) en raison des débits de filtration significativement plus faibles à des pressions de perfusion plus élevées. Nous concluons: (1) chez les rats R normaux la relation pression-natriurèse est celle prédite par l'hypothèse de Guyton; (2) les animaux Dahl S n'ont pas d'anomalie préexistante de cette fonction; (3) une dépression de la relation natirurèse-pression peut aggraver l'hypertension chez les rats S une fois que la pression artérielle élevée a persisté